Clinical Studies

2016 Clinical Studies for: Serene by Nature topical cream for equines.

Seven mares participated in the study, and six of those horses were under the guidance of Dr. Joyce Harman. Saliva testing kits for hormones were provided by Dr. Jean Dodds, testing each mare a total of 4 times over the course of the study.

The study ran for 3 estrous cycles, and the Serene by Nature cream was applied once daily for 15 days out of each 21 day estrous cycle.  The saliva samples were taken before the start of the Serene by Nature cream application and after the completion of each 15 day cycle.  Daily logs were kept for each horse.

The results were favorable.  The saliva tests confirmed the balancing of hormones and the daily logs showed each mare not only responding in a positive manner, but improving with each subsequent cycle of Serene by Nature cream usage.

The positive results mirror the same success that humans have been enjoying for over three decades now.  Good news indeed!

Field Study Trial testimonials:

Testimonial #1:    Two mares studied – Blue & Uschi

The cream was very easy to apply and did not cause any discomfort to the horses.  I was able to apply the cream with the girls loose in the field, no fuss no muss. 

Both mares seemed to mellow through the course of the study

They did not respond to, nor were they reactive to, the geldings on the property.  They both tend to be a bit mare-ish and demonstrative in their posturing for the boys.  There was none of that while they were participating in the study. 

Blue’s owner found her to be less reactive and easier to work around.  Uschi was pleasant the whole time, she only had one time where her bitch-switch was triggered and it was when asking her to open a gate, which she hates to do.  I was hopeful the cream might eliminate that reaction, but it wasn’t meant to be.  😉

Uschi had been (prior to using the cream) on an oral herbal blend which worked out okay for her, certainly preferable to Regumate.  I found that the Serene by Nature cream helped to mellow her more and keep her on an even keel… more like a gelding. 

Over all, I feel that the hormonal highs and lows were evened out for both girls while they were on the cream.

Post study – six  months later…

And following your cream, Uschi stayed on that even keel even when off cream for the winter. Whereas when we stopped the herbal supplement she would go back to being mare-ish during the off season months.  She still seems non mare-ish even after all these months (written in February) of not applying the cream!   Leslie G.


Testimonial #2:     Four mares studied

I had 4 mares that were part of the study for Serene By Nature.

The 2 mares with the most volatile personalities definitely showed improvement. One was  4 yr old TB mare who was typically very mellow but would have days where she truly was an “evil mare”.

She improved in the first month on the product and after the 3rd month there was almost no difference in her personality throughout the month.

I have continued her on the cream and she has remained very steady. For a green OTTB she is handling crowded noisy shows very well and is as easy to ride at a show as she is at home.

The cream is very easy to apply and I have not had any adverse reactions to horses or humans.   Cathy S.


Testimonial #3:   One mare studied – Jolee

From the first day I used the cream on Jolee she liked it. So much so, she would turn around to watch me apply it. Going forward, each day she would place her rump in my direction and look to watch me apply the cream.

She would almost immediately become calmer too. This is a very hot, high strung mare who would stand in cross ties and paw and stomp to get attention. Most of this pawing behavior quieted following the use of the cream. She would even take a deep exhale and stand still on all four.  I was amazed at how well she took to it and actually appeared to await my arrival for her cream each morning.

During the periods where she was off the cream, she went back to pawing, jumping around and allover anxiously awaiting her grooming and tacking up.

By the end of our trial on this product, I kept wondering how I would ever get along with out Serene by Nature cream.

My mare was almost like a different horse when on it.  I like that it’s natural and doesn’t harm her and that she seems so much more content when on it.  Wendy W.


Disclaimer: Serene by Nature, nor any third party associated with, related to, or linked to their businesses or websites, expressly disclaims any responsibility for, and makes no representations or warranties regarding, any statement, information, materials, or content found on or included in Serene by Nature’s marketing materials/websites, or any third party marketing materials/websites related to, associated with or linked to Serene by Nature’s business or website. Serene by Nature is not intended to diagnose, treat, cure, prevent any disease or replace proper medical care. These statements have not yet been approved by the FDA.

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